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MessagePosté le: Lun 19 Juin - 05:07 (2017)    Sujet du message: Pathology For Toxicologists: Principles And Practices Of La Répondre en citant




Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important  to the pharmaceutical company or whether the lesions are background changes and thus of little significance.

Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound.

This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of their training or career who want to know more about the pathology encountered in laboratory animals used in safety studies.  Key features include important chapters on  spontaneous and target organ lesions in rats, mice, non-human primates, mini pigs, rabbits and beagle dogs as well as information on general pathology, macroscopic target organ lesions, ancillary pathology techniques, haematology, biochemistry and adversity.

Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel includes:
<ul> <li>Colour diagrams explaining how lesions are caused by either external compounds or spontaneously</li> <li>The anatomic variations and background lesions of laboratory animals</li> <li>Advice on sampling tissues, necropsy, ancillary pathology techniques and recording data</li> <li>A chapter on the haematology and biochemistry of laboratory animals</li> <li>Full colour photographs of common macroscopic lesions encountered in laboratory animals</li> <li>A comprehensive glossary</li> </ul>







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"The Connectome Debate: Is Mapping the Mind of a Worm Worth It?""Animal models of human disease: zebrafish swim into view."Handbook of Laboratory Animal Science, Volume I, Third Edition: Essential Principles and PracticesShe qualified as a veterinary surgeon in South Africa in 1988 and completed a PhD at Imperial College, London in 1996PMID8129041Agents ChemotherHuman-specific genetic factors likely play a role in individual susceptibility, and there is no widely accepted animal model (FDA, 2009; Daly and Day, 2012)Retrieved 30 April 201050 (5): 17317(2013)

When researchers look for an organism to use in their studies, they look for several traitsNeglecting to do so may result in generation of data that are misleading or uninterpretable but nonetheless must be submitted to regulatory authoritiesModel organisms are drawn from all three domains of life, as well as Write You A Song download epub mobi pdf fb2 which has been intensively investigated for over 60 yearsWhen packaging samples, the use of breakable containers should be avoided, but properly padded glass tubes are commonly shippedA good example of the limitations of animal models in this respect is the tragic outcome of a first-in-human clinical trial of a monoclonal antibody, TGN1412 a humanised CD28 agonist antibody intended to act as a selective stimulant of regulatory T-cell expansion for the treatment of autoimmune diseases (Suntharalingam et al., 2006)A.; Abril, R



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